Lee Daniels is the first black filmmaker to be nominated as a motion picture director by the DGA. If the Academy nominates him, Daniels will become the second black person to receive a Best Director Oscar nod, after John Singleton for Boyz N the Hood (1991).
It isn’t clear how many gay/bisexual directors have been nominated by the DGA in the past (George Cukor, for one, was nominated four times), but Daniels is surely one of the first openly gay filmmakers to get a DGA nod. Rob Marshall and Bill Condon are the only two others I can think of. Marshall won for Chicago (2002), while Condon was cited for Dreamgirls (2006).